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References - Specific Topics & Research

 

For References on Orthostatic Intolerance, OH, NMH, and POTS - Click Here

 

Additional References - Specific Topics & Research
  1. Abe H, Kondo S, Kohshi K, et al. Usefulness of orthostatic self-training for prevention of neurocardiogenic syncope. Pacing Clin Electrophysiol. 2002;25:1454 –1458. Abstract.
  2. Abe H, Kohshi K, Nakashima Y. Efficacy of orthostatic self-training in medically refractory neurocardiogenic syncope. Clin Exp Hypertens. 2003;25:487– 493. Abstract
  3. Angel MJ, Bril V, Shannon P, Herridge MS.  Neuromuscular function in survivors of the acute respiratory distress syndrome. Can J Neurol Sci. 2007 Nov;34(4):427-32.Can J Neurol Sci. 2007 Nov;34(4):427-32. Abstract.
  4. Belavý DL, Bock O, Börst H, Armbrecht G, Gast U, Degner C, Beller G, Soll H, Salanova M, Habazettl H, Heer M, de Haan A, Stegeman DF, Cerretelli P, Blottner D, Rittweger J, Gelfi C, Kornak U, Felsenberg D.The 2nd Berlin BedRest Study: protocol and implementation.J Musculoskelet Neuronal Interact. 2010 Sep;10(3):207-19. Abstract. Article PDF.
  5. Belavý DL, Armbrecht G, Gast U, Richardson CA, Hides JA, Felsenberg D.Countermeasures against lumbar spine deconditioning in prolonged bed rest: resistive exercise with and without whole body vibration.J Appl Physiol. 2010 Dec;109(6):1801-11. Epub 2010 Sep 23. Abstract. Article PDF.
  6. Belavý DL, Armbrecht G, Richardson CA, Felsenberg D, Hides JA. Muscle atrophy and changes in spinal morphology: is the lumbar spine vulnerable after prolonged bed-rest? Spine (Phila Pa 1976) (June 30,2010). Abstract.
  7. Belavý DL, Bansmann PM, Böhme G, Frings-Meuthen P, Heer M, Rittweger J, Zange J, Felsenberg D. Changes in intervertebral disc morphology persist 5 mo after 21-day bed rest. J Appl Physiol. 2011 Nov;111(5):1304-14. Epub 2011 Jul 28. Abstract.
  8. Benrud-Larson LM, Dewar MS, Sandroni P, et al. Quality of life in patients with postural tachycardia syndrome. Mayo Clin Proc 2002;77:531-7. Abstract. Article PDF.
  9. Blockmans D, Persoons P, van Houdenhove B, Bobbaers H. Does methylphenidate reduce the symptoms of chronic fatigue syndrome? Am J Med 2006;119:167.e23-167.e30.
  10. Boehm KE, et al. Neurocardiogenic syncope: response to hormonal therapy. Pediatrics 1997;99:623-
  11. Boneva, R. S., Decker, M. J., Maloney, E. M., Lin, J. M., Jones, J. F., Helgason, H. G., Heim, C. M., Rye, D. B. and Reeves, W. C. Higher heart rate and reduced heart rate variability persist during sleep in chronic fatigue syndrome: a population-based study. Auton. Neurosci. 2007: 137; 94–101. Abstract.
  12. Bou-Holaigah I, Rowe PC, Kan J, Calkins H. The relationship between neurally mediated hypotension and the chronic fatigue syndrome. JAMA. 1995;274:961–967. Abstract.
  13. Bouvette CM, McPhee BR, Opfer-Gehrking TL, Low PA.  Role of physical countermaneuvers in the management of orthostatic hypotension: efficacy and biofeedback augmentation. Mayo Clin Proc. 1996 Sep; 71(9):847-53.  Abstract.
  14. Burkhardt BE, Pianosi PT, Brands CK, Porter CJ, Weaver AL, Fischer PR. Heart rate response to exercise in adolescents with autonomic dysfunction. Clin Autonom Res 2007;17:266.  Abstract.
  15. Capuron L, Welberg L, Heim C, Wagner D, Solomon L, Papanicolaou DA, Craddock RC, Miller AH, Reeves WC. Cognitive dysfunction relates to subjective report of mental fatigue in patients with chronic fatigue syndrome. Psychosom Med. 2008 Sep;70(7):829-36. Epub 2008 Jul 7.Abstract.  Article PDF.
  16. CDC. Chronic Fatigue Syndrome. Treating the Most Disruptive Symptoms First. http://www.cdc.gov/cfs/management/treating-symptoms.html Last accessed August 23, 2012.
  17. Chelimsky G, Chelimsky TC.  Evaluation and treatment of autonomic disorders of the gastrointestinal tract.Semin Neurol. 2003 Dec;23(4):453-8. Abstract.
  18. Chelimsky TC, Chelimsky GG. Autonomic abnormalities in cyclic vomiting syndrome.J Pediatr Gastroenterol Nutr. 2007 Mar;44(3):326-30.
  19. Chelimsky G, Madan S, Alshekhlee A, Heller E, McNeeley K, Chelimsky T.   A comparison of dysautonomias comorbid with cyclic vomiting syndrome and with migraine.Gastroenterol Res Pract. 2009;2009:701019. Epub 2010 Jan 6.  Abstract. Article PDF.
  20. Claydon VE, Hainsworth R.   Increased postural sway in control subjects with poor orthostatic tolerance. J Am Coll Cardiol. 2005;46:1309– 1313. Abstract.
  21. Cooper VL, Hainsworth R Effects of dietary salt on orthostatic tolerance, blood pressure and baroreceptor sensitivity in patients with syncope. Clin Auton Res 2002; 12:236–241
  22. Cooper VL, Hainsworth R Head-up sleeping improves orthostatic tolerance in patients with syncope. Clin Auton Res 2008; 18:318–324
  23. Costigan A, Elliott C, McDonald C, Newton JL.Orthostatic symptoms predict functional capacity in chronic fatigue syndrome: implications for management. QJM. 2010 Aug;103(8):589-95. Epub 2010 Jun 9.  Abstract.  Article PDF
  24. De Becker P, Dendale P, De Meirleir K, Campine I, Vandenborne K, Hagers Y.Autonomic testing in patients with chronic fatigue syndrome.Am J Med. 1998 Sep 28;105(3A):22S-26S.
  25. Di Girolamo E, et al. Effects of paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on refractory vaso-vagal syncope: a randomized, double-blind, placebo-controlled study. JACC 1999;33: 1227-30.
  26. Dorfman TA, Levine BD, Tillery T, Peshock RM, Hastings JL, Schneider SM, Macias BR, Biolo G, Hargens AR. Cardiac atrophy in women following bed rest. J Appl Physiol. 2007 Jul;103(1):8-16. Epub 2007 Mar 22.Abstract. Article PDF.
  27. Ector H, Reybrouck T, Heidbüchel H, Gewillig M, Van de Werf F. Tilt training: a new treatment for recurrent neurocardiogenic syncope and severe orthostatic intolerance. Pacing Clin Electrophysiol 1998; 21:193–196.
  28. El-Sayed H, Hainsworth R. Salt supplementation increases plasma volume and orthostatic tolerance in patients with unexplained syncope. Heart 1996; 75:134–140.
  29. Filler G, et al. Pharmacokinetics of pyridostigmine in a child with postural tachycardia syndrome. Pediatrics 2006;118:e1563-8.
  30. Fletcher SN, Kennedy DD, Ghosh IR, Misra VP, Kiff K, Coakley JH, Hinds CJ.Persistent neuromuscular and neurophysiologic abnormalities in long-term survivors of prolonged critical illness. Crit Care Med. 2003 Apr;31(4):1012-6. Abstract
  31. Freeman R, Komaroff AL. Does the chronic fatigue syndrome involve the autonomic nervous system? Am J Med 1997;102:357-64.
  32. Fu Q, VanGundy TB, Shibata S, Auchus RJ, Williams GH, Levine BD.  Menstrual cycle affects renal-adrenal and hemodynamic responses during prolonged standing in the postural orthostatic tachycardia syndrome.  Hypertension 56(1): 82-90, 2010.      Article PDF.
  33. Fu Q, Vangundy TB, Galbreath MM, Shibata S, Jain M, Hastings JL, Bhella PS, Levine BD. Cardiac origins of the postural orthostatic tachycardia syndrome. J Am Coll Cardiol. 2010 Jun 22;55(25):2858-68. Abstract. Article PDF
  34. Fu Q, VanGundy TB, Shibata S, Auchus RJ, Williams GH, Levine BD.  Exercise training versus propranolol in the treatment of the postural orthostatic tachycardia syndrome.  Hypertension 58(2); 167-75, 2011. Abstract. Article PDF.
  35. Galbreath MM, Shibata S, VanGundy TB, Okazaki K, Fu Q, Levine BD.  Effects of exercise training on arterial-cardiac baroreflex function in POTS.  Clinical Autonomic Research 21(2):73-80, 2011. Abstract.
  36. Gilden JL. Midodrine in neurogenic orthostatic hypotension. A new treatment. Int Angiology 1993;12:125–131..
  37. Grubb BP, Kosinski D, Mouhaffel A, Pothoulakis A. Use of methylphenidate in the treatment of refractory neurocardiogenic syncope. PACE 1996;19:836-40.
  38. Hides JA, Lambrecht G, Richardson CA, Stanton WR, Armbrecht G, Pruett C, Damann V, Felsenberg D, Belavý DL.The effects of rehabilitation on the muscles of the trunk following prolonged bed rest. The effects of rehabilitation on the muscles of the trunk following prolonged bed rest. Abstract. Article PDF.
  39. Jordan J, Shannon JR, Diedrich A, Black BK, Robertson D: Increased sympathetic activation in idiopathic orthostatic intolerance: Role of systemic adrenoreceptor sensitivity. Hypertension 2002;39:173- 178. Abstract. Article PDF.
  40. Joyner Michael J, Masuki Shizue. POTS versus deconditioning: the same or different?  Clin Auton Res. 2008 Dec;18(6):300-7. Epub 2008 Aug 12.   Abstract.
  41. Krediet CT, Dijk N, Linzer M, et al.   Management of vasovagal syncope, controlling or aborting faints by led crossing and muscle tensing. Circulation. 2002;106:1684 –1689.
  42. Lee et al. Aerobic Exercise Deconditioning and Countermeasures During Bed Rest. Aviation, Space, and Environmental Medicine January 2010;81(1): 52-63.  Abstract.  Article PDF.
  43. Low PA, Gilden JL, Freeman R, Sheng KN, McElligott MA. Efficacy of midodrines placebo in neurogenic orthostatic hypotension: a randomized, double-blind multicenter study. JAMA 1997;277:1046-51.[Erratum, JAMA 1997; 278:388] 51. [Erratum, JAMA 1997;278:388.]
  44. Lu C-C, Diedrich A, Tung C-S, et al. Water Ingestion as prophylaxis against syncope. Circulation. 2003;108:2660 –2665.
  45. Jancovic J, Gilden JL, Hiner BC, et al. Neurogenic orthostatic hypotension: a double-blind placebo-controlled study with midodrine. Am J Med. 1993;95:38–48.
  46. Jordan J, Shannon JR, Pohar B, Paranjape SY, Robertson D, Robertson RM, Biaggioni I. Contrasting effects of vasodilators on blood pressure and sodium balance in the hypertension of autonomic failure. J Am Soc
    Nephrol. 1999;10:35– 42
  47. Lee et al. Aerobic exercise deconditioning and countermeasures during bed rest. Aviation, Space, and Environmental Medicine January 2010;81(1): 52.63. Abstract.
  48. Low PA, Gilden JL, Freeman R, Sheng KN, McElligott MA. Efficacy of midodrine vsplacebo in neurogenic orthostatic hypotension: a randomized, double-blind multicenter study. JAMA 1997;277:1046-51.[Erratum, JAMA 1997; 278:388]  Abstract.
  49. Mahanonda N, et al. Randomized double-blind, placebo-controlled trial of oral atenolol in patients with unexplained syncope and positive upright tilt table test results. Am Heart J 1995;130:1250-3.
  50. Masuki S, Eisenach JH, Johnson CP, Dietz NM, Benrud-Larson LM,Schrage WG, Curry TB, Sandroni P, Low PA, Joyner MJ: Excessive heart rate response to orthostatic stress in postural tachycardia syndrome is not caused by anxiety. J Appl Physiol 2007;102:896-903. Abstract. Article PDF.
  51. Medow, M. Going With the Flow - BLood Flow, That is. Webinar CFIDS.org. March 25, 1010.   Slides   Video. .
  52. Newton JL, Okonkwo O, Sutcliffe K, Seth A, Shin J, Jones DEJ.Symptoms of autonomic dysfunction in chronic fatigue syndrome.Q J Med 2007; 100:519–26. Abstract.   Article PDF.
  53. Novak V, Spies JM, Novak P, McPhee BR, Rumman TA, Low PA. Hypocapnia and Cerebral Hypoperfusion in Orthostatic Intolerance. Stroke. 1998 Sep;29(9):1876-81.   Abstract.    Article PDF
  54. Ocon AJ, Messer ZR, Medow MS, Stewart JM. Increasing orthostatic stress impairs neurocognitive functioning in chronic fatigue syndrome with postural tachycardia syndrome. Clin Sci (Lond). 2012 Mar;122(5):227-38.   Abstract.   Article PDF.
  55. Ojha A, Chelimsky TC, Chelimsky G.   Comorbidities in pediatric patients with postural orthostatic tachycardia syndrome. J Pediatr. 2011 Jan;158(1):20-3. Epub 2010 Aug 17. Abstract.
  56. Okamoto LE, Gamboa A, Shibao C, Black BK, Diedrich A, Raj SR, Robertson D, Biaggioni I.  Nocturnal blood pressure dipping in the hypertension of autonomic failure. Hypertension. 2009 Feb;53(2):363-9. Epub 2008 Dec 1. Abstract. Article PDF.
  57. Okamoto LE, Raj SR, Peltier A, et al  Neurohumoral and haemodynamic profile in postural tachycardia and chronic fatigute syndromesvvClin Sci (Lond). 2012 Feb;122(4):183-92. doi: 10.1042/CS20110200. Abstract.Article PDF
  58. Olson LG, Ambrogetti A, Sutherland DC. A pilot randomized controlled trial of dexamphetamine in patients with chronic fatigue syndrome. Psychosomatics 2003;44:38-43.
  59. Qingyou Z, et al. The efficacy of midodrine in the treatment of children with vasovagal syncope. J Pediatr 2006;149:777-80.
  60. Rahman K, Burton A, Galbraith S, Lloyd A, Vollmer-Conna U. Sleep-wake behavior in chronic fatigue syndrome.Sleep. 2011 May 1;34(5):671-8. Abstract.  Article PDF.
  61. Raj SR, Black BK, Biaggioni I, Harris PA, Robertson D. Acetylcholinesterase inhibition improves tachycardia in postural tachycardia syndrome.Circulation. 2005;111:2734–40.  Abstract.
  62. Raj, S. R., Biaggioni, I., Yamhure, P. C., Black, B. K.,  Paranjape, S. Y., Byrne, D.W. and Robertson, D.Renin-aldosterone paradox and perturbed blood volume regulation underlying postural tachycardia syndrome. Circulation 2005: 111; 1574–1582
  63. Raj SR, Black BK, Biaggoni I,Paranjape SY, Ramirez M, Dupont WD, Robertson D. Propranolol decreases tachycardia and improves symptoms in the postural tachycardia syndrome: less is more. Circulation 2009;120:725-34.
  64. Robertson D, et al. Clonidine raises blood pressure in severe idiopathic orthostatic hypotension. Am J Med 1983;74:193-200.
  65. Rowe PC , Calkins H , DeBusk K , et al. Fludrocortisone acetate to treat neurally mediated hypotension in chronic fatigue syndrome (a randomized controlled trial). JAMA. 2001;285:52–59.
  66. Safder S, Chelimsky TC, O'Riordan MA, Chelimsky G.   Autonomic testing in functional gastrointestinal disorders: implications of reproducible gastrointestinal complaints during tilt table testing. Gastroenterol Res Pract. 2009;2009:868496. Epub 2009 May 5. Abstract  .Article PDF.
  67. Shannon J, Jordan J, Costa F, Robertson RM, Biaggioni I. The hypertension of autonomic failure and its treatment. Hypertension. 1997;30: 1062–1067.
  68. Shibao C, Gamboa A, Abraham R, Raj SR, Diedrich A, Black B, Robertson D, Biaggioni I. Clonidine for the treatment of supine hypertension and pressure natriuresis in autonomic failure. Hypertension. 2006;47:522–526.
  69. Shibata S, Perhonen M, Levine BD.Supine cycling plus volume loading prevent cardiovascular deconditioning during bed rest.J Appl Physiol. 2010 May;108(5):1177-86. Epub 2010 Mar 11. Abstract  .Article PDF
  70. Shibata S, Fu Q, Bivens TB, Hastings JL, Wang W, Levine BD. Short-term exercise training improves the cardiovascular response to exercise in the postural orthostatic tachycardia syndrome. J Physiol. 2012 Aug 1;590(Pt 15):3495-505. Epub 2012 May 28.  Abstract.  Article PDF
  71. Singer W, Sandroni P, Opfer-Gehrking TL, Suarez GA, Klein CM, Hines S, O'Brien PC, Slezak J, Low PA Arch Neurol. 2006 Apr; 63(4):513-8.
  72. Singer W, et al. Acetylcholinesterase inhibition in patients with orthostatic intolerance. J Clin Neurophysiol 2006;23:477-82.
  73. Smit AA, Wieling W, Fujimura J, et al. Use of lower abdominal compression to combat orthostatic hypotension in patients with autonomic dysfunction. Clin Auton Res 2004;14:167-75.  Abstract.
  74. Stewart J, Weldon A, Arlievsky N, Li K, Munoz J. Neurally mediated hypotension and autonomic dysfunction measured by heart rate variability during head-up tilt testing in children with chronic fatigue syndrome. Clin Auton Res. 1998 Aug;8(4):221-30. Abstract.
  75. Stewart JM, Gewitz MH, Weldon A, Munoz J. Patterns of orthostatic intolerance: The orthostatic tachycardia syndrome and adolescent chronic fatigue. J Pediatr. 1999;135:218–225 Abstract   Article PDF
  76. Stewart JM. Autonomic nervous system dysfunction in adolescents with postural orthostatic tachycardia syndrome and chronic fatigue syndrome is characterized by attenuated vagal baroreflex and potentiated sympathetic vasomotion.Pediatr Res. 2000 Aug;48(2):218-26. Abstract.
  77. Stewart JM, Weldon A. Vascular perturbations in the chronic orthostatic intolerance of the postural orthostatic tachycardia syndrome. J Appl Physiol 89:1505-1512, 2000.  Abstract. Article PDF.
  78. Stewart JM. Chronic fatigue syndrome: comments on deconditioning, blood volume and resulting cardiac function.Clin Sci (Lond). 2009 Oct 19;118(2):121-3. Abstract. Article.
  79. Sukul D, Chelimsky TC, Chelimsky G.   Pediatric autonomic testing: retrospective review of a large series.Clin Pediatr (Phila). 2012 Jan;51(1):17-22. doi: 10.1177/0009922811415102. Epub 2011 Aug 25. Abstract.
  80. Sullivan SD, Hanauer J, Rowe PC, Barron DF, Darbari A, Oliva-Hemker M. Gastrointestinal symptoms associated with orthostatic intolerance. J Pediatr Gastroenterol Nutr. 2005 Apr;40(4):425-8. Abstract.
  81. Susmano A, Volgman AS, Buckingham TA. Beneficial effects of dextro-amphetamine in the treatment of vasodepressor syncope. PACE 1993;16:1235-9.
  82. Tank J, Baevsky RM, Funtova II, Diedrich A, Slepchenkova IN, Jordan J  Orthostatic heart rate responses after prolonged space flights. Clin Auton Res.2011 Apr;21(2):121-4. Epub 2010 Dec 25. Abstract
  83. Ten Harkel AD, Van Lieshout JJ, Wieling W. Treatment of orthostatic hypotension with sleeping in the head-up tilt position, alone and in combination with fludrocortisone. J Intern Med. 1992 Aug;232(2):139-45. Abstract.
  84. Ten Harkel AD, van Lieshout JJ, Wieling W.   Effects of leg muscle pumping and tensing on orthostatic arterial pressure: a study in normal subjects and patients with autonomic failure. Clin Sci (Lond)1994 Nov; 87(5):553-8.
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  88. van Lieshout JJ, ten Harkel AD, Wieling W. Physical manoeuvres for combating orthostatic dizziness in autonomic failure. Lancet. 1992; 339:897– 898.
  89. van Lieshout JJ, ten Harkel AD, Wieling W. Fludrocortisone and sleeping in the head-up position limit the postural decrease in cardiac output in autonomic failure. Clin Auton Res 2000;10:35-42. Abstract
  90. Ward CR, et al. Midodrine: a role in the management of neurocardiogenic syncope. Heart 1998; 79:45-9.
  91. Wieling W, van Lieshout JJ, Hainsworth R. Extracellular fluid volume expansion in patients with posturally related syncope. Clin Auton Res 2002;12:242-9.
  92. Winker R, Barth A, Bidmon D, Ponocny I et al. Endurance exercise training in orthostatic intolerance: a randomized, controlled trial.  Hypertension 2005:45(3):391-398. Abstract.  Article PDF.
  93. Wyller VB, Godang K, Morkrid L, Saul JP, Thaulow E, Walloe L. Abnormal thermoregulatory responses in adolescents with chronic fatigue syndrome: Relation to clinical symptoms. Pediatrics 2007;120:e129-37.
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  97. Holguin N, Muir J, Rubin C, Judex S. Short applications of very low-magnitude vibrations attenuate expansion of the intervertebral disc during extended bed rest. Spine J 9: 470–477, 2009.Huang CY, Gu WY. Effects of mechanical compression on metabolism and distribution of oxygen and lactate in intervertebral disc. J Biomech 41: 1184–1196, 2008.
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Author: Kay E. Jewell, MD
Page Last Updated: August 28, 2012

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